- Shipping MethodEMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
- GradePharmaceutical Grade
- CertificationISO 9001, USP, GMP
Prohormone Bodybuilding Breast Cancer Synthetic Estrogen Diethylstilbestrol CAS 56-53-1
Product Name: Diethylstilbestrol
Synonyms: LABOTEST-BB LT00233101;DIETHYLSTILBESTEROL;DOMESTROL;GRAFESTROL;ESTROSYN;FONATOL;ALPHA;ALPHA,ALPHA'-DIETHYL-(E)-4,4'-STILBENEDIOL
Density: 1.107g / cm3
Melting point: 169-175 ℃
Boiling point: 407.1 ° C at 760 mmHg
Flash Point: 187 ° C
Appearance: White crystalline powder
Usage: A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.
Air & Water Reactions: Insoluble in water.
Reactivity Profile: Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .
Diethylstilbestrol (DES, former BAN stilboestrol) is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers.
From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses.
In 1971, DES was shown to cause a rare vaginal tumor in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew DES from use in pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed.
The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons".
DES is now known to be an endocrine-disrupting chemical, one of a number of substances that interfere with the endocrine system to cause cancer, birth defects, and other developmental abnormalities. The effects of endocrine-disrupting chemicals are most severe when exposure occurs during fetal development.
DES has been used in the past for the following indications:
Recurrent miscarriage in pregnancy
Hormone replacement therapy for menopausal symptoms such as hot flashes and vaginal atrophy
Hormone replacement therapy for hypoestrogenism (e.g., gonadal dysgenesis, premature ovarian failure, and after oophorectomy)
Postpartum lactation suppression to prevent or reverse breast engorgement
Gonorrheal vaginitis (discontinued following the introduction of the antibiotic penicillin)
Prostate cancer and breast cancer
Prevention of tall stature in tall adolescent girls
As an emergency postcoital contraceptive
Court sanctioned Chemical castration for men convicted of sex-related crimes
1. Female canine incontinence
DES has been very successful in treating female canine incontinence stemming from poor sphincter control. It is still available from compounding pharmacies, and at the low (1 mg) dose, does not have the carcinogenic properties that were so problematic in humans. It is generally administered once a day for seven to ten days and then once every week as needed.
2. Growth promotion in livestock
The greatest usage of DES was in the livestock industry, used to improve feed conversion in beef and poultry. During the 1960s, DES was used as a growth hormone in the beef and poultry industries. It was later found to cause cancer by 1971, but was not phased out until 1979. When DES was discovered to be harmful to humans, it was moved to veterinary use.
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